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Sanofi (SAN.PA)

Paris - Paris Prix différé. Devise en EUR
Ajouter à la liste dynamique
78,90-0,14 (-0,18 %)
À partir de 9:29AM CET. Marché ouvert.
Plein écran
Clôture précédente79,04
Ouverture79,75
Offre0,00 x 0
Vente0,00 x 0
Var. jour78,21 - 79,80
Sur 52 semaines67,65 - 95,82
Volume237 898
Volume moyen1 777 518
Cap. boursière99,125B
Bêta (mensuel sur 5 ans)0,37
Rapport P/E (sur 12 mois)9,00
BPA (sur 12 mois)8,77
Date de bénéfices29 oct. 2020
Dividende et rendement à terme3,15 (3,99 %)
Date ex-dividende04 mai 2020
Objectif sur 1 an82,62
  • Globe Newswire

    Sanofi va évaluer la sécurité et l’efficacité d’un nouveau candidat expérimental, THOR-707, en association avec KEYTRUDA® (pembrolizumab), dans le but d’établir une nouvelle option thérapeutique en oncologie

    Sanofi va évaluer la sécurité et l’efficacité d’un nouveau candidat expérimental, THOR-707, en association avec KEYTRUDA® (pembrolizumab), dans le but d’établir une nouvelle option thérapeutique en oncologie *THOR-707 (SAR444245) est un candidat IL-2 non-alpha qui pourrait devenir le meilleur de sa classe pharmacothérapeutique ; il fait actuellement l’objet d’essais de phase I dans le traitement de tumeurs solides. PARIS – Le 29 octobre 2020 – Sanofi a conclu un accord avec Merck & Co., Inc., Kenilworth, (New jersey), États-Unis (connu sous le nom de MSD en dehors des États-Unis et du Canada) pour la conduite d’un essai clinique de phase II visant à évaluer la sécurité, la pharmacocinétique et l’efficacité préliminaire de THOR-707, un candidat IL-2 non-alpha hautement différencié qui pourrait devenir le meilleur de sa classe pharmacothérapeutique, associé ou administré en séquence avec le KEYTRUDA® (pembrolizumab) de MSD à des patients atteints de différents cancers. Aux termes de cet accord, Sanofi se chargera de la conduite des essais cliniques, tandis que MSD fournira le KEYTRUDA. « Nous pensons que THOR-707 a le potentiel de devenir un médicament qui jettera les bases de la nouvelle génération des traitements en immuno-oncologie », a précisé Peter Adamson, Responsable Monde, Développement en oncologie et Innovation en pédiatrie de Sanofi. « Cette collaboration avec MSD nous permettra de déterminer si THOR-707 peut potentialiser et renforcer l’efficacité de KEYTRUDA, et améliorer les résultats cliniques des patients atteints d’un cancer. » THOR-707 est actuellement évalué par Sanofi dans le cadre d’un essai clinique de phase I multicentrique, en ouvert, d’escalade de dose et d’expansion de ses indications. Cette étude a pour but d’évaluer la sécurité et la tolérance de THOR-707 et de déterminer la dose qu’il sera recommandé d’administrer en phase II, soit en monothérapie, soit en association avec des anticorps anti-PD-1 et anti-EGFR. En plus de tester THOR-707 en association avec KEYTRUDA, Sanofi mène des essais cliniques distincts en vue d’évaluer l’activité de ce nouvel agent biologique en association avec d’autres anticorps anti-PD-1, comme Libtayo® (cemiplimab-rwlc), ainsi qu’avec des anticorps anti-EGFR et anti-CD38, pour le traitement de différents types de tumeurs solides. Dans le cadre d’études précliniques, THOR-707 a montré qu’il peut induire une expansion des lymphocytes T CD8+ débouchant sur des effets antitumoraux, à la fois en monothérapie et en association avec un anticorps monoclonal anti-PD1. Il s’agit de la première molécule issue de la plateforme Synthorin, la plateforme unique d’expansion de l’alphabet génétique de Sanofi qui a le potentiel de permettre le développement d’une nouvelle génération de médicaments de précision en oncologie et en immunologie. À propos de THOR-707 THOR-707 a le potentiel de devenir le meilleur agent thérapeutique IL-2 de sa classe pharmacothérapeutique pour le traitement de multiples tumeurs malignes et pourrait présenter un profil pharmacologique amélioré permettant de réduire la fréquence des doses. Dans le cadre d’expérimentations précliniques, THOR-707 a montré une synergie remarquable avec les anti-PD-1. Il s’agit d’une version PÉGylée de l’interleukine 2 (IL-2), dans laquelle la chaîne PEG est attachée à un site de l’interleukine 2 pour l’empêcher de se lier aux récepteurs immuns à l’origine de toxicités médicamenteuses (IL-2R-alpha, CD25), tout en préservant sa liaison aux récepteurs immuns qui favorisent sélectivement l’expansion des lymphocytes T cytotoxiques et Natural Killer (NK), sans induire les effets immunosuppresseurs des lymphocytes T  régulateurs, ni de syndrome de  fuite vasculaire avec éosinophilie. Note de la rédaction : Comme cela a été indiqué lors de la journée que Sanofi a consacré à sa R&D en juin dernier, les résultats complets de phase I applicables au THOR-707 et la dose recommandée pour les essais de phase II devraient être connus d’ici à 2021.  À propos de Sanofi La vocation de Sanofi est d’accompagner celles et ceux confrontés à des difficultés de santé. Entreprise biopharmaceutique mondiale spécialisée dans la santé humaine, nous prévenons les maladies avec nos vaccins et proposons des traitements innovants. Nous accompagnons tant ceux qui sont atteints de maladies rares, que les millions de personnes souffrant d’une maladie chronique. Sanofi et ses plus de 100 000 collaborateurs dans 100 pays transforment l’innovation scientifique en solutions de santé partout dans le monde. Sanofi, Empowering Life, donner toute sa force à la vie.  Relations Médias Sally Bain Tél. : +1 (781) 264-1091 sally.bain@sanofi.com           Relations Investisseurs - Paris Eva Schaefer-Jansen Arnaud DelepineYvonne Naughton Relations Investisseurs – Amérique du Nord Felix LauscherFara BerkowitzSuzanne Greco Tél. : +33 (0)1 53 77 45 45 ir@sanofi.com Déclarations prospectivesCe communiqué contient des déclarations prospectives. Ces déclarations ne constituent pas des faits historiques. Ces déclarations comprennent des projections et des estimations ainsi que les hypothèses sur lesquelles celles-ci reposent, des déclarations portant sur des projets, des objectifs, des intentions et des attentes concernant des résultats financiers, des événements, des opérations, des services futurs, le développement de produits et leur potentiel ou les performances futures. Ces déclarations prospectives peuvent souvent être identifiées par les mots « s’attendre à », « anticiper », « croire », « avoir l’intention de », « estimer » ou « planifier », ainsi que par d’autres termes similaires. Bien que la direction de Sanofi estime que ces déclarations prospectives sont raisonnables, les investisseurs sont alertés sur le fait que ces déclarations prospectives sont soumises à de nombreux risques et incertitudes, difficilement prévisibles et généralement en dehors du contrôle de Sanofi, qui peuvent impliquer que les résultats et événements effectifs réalisés diffèrent significativement de ceux qui sont exprimés, induits ou prévus dans les informations et déclarations prospectives. Ces risques et incertitudes comprennent notamment les incertitudes inhérentes à la recherche et développement, les futures données cliniques et analyses, y compris postérieures à la mise sur le marché, les décisions des autorités réglementaires, telles que la FDA ou l’EMA, d’approbation ou non, et à quelle date, de la demande de dépôt d’un médicament, d’un procédé ou d’un produit biologique pour l’un de ces produits candidats, ainsi que leurs décisions relatives à l’étiquetage et d’autres facteurs qui peuvent affecter la disponibilité ou le potentiel commercial de ces produits candidats, le fait que les produits candidats s’ils sont approuvés pourraient ne pas rencontrer un succès commercial, l’approbation future et le succès commercial d’alternatives thérapeutiques, la capacité de Sanofi à saisir des opportunités de croissance externe et à finaliser les transactions y relatives, l’évolution des cours de change et des taux d’intérêt, l’instabilité des conditions économiques et de marché, , des initiatives de maîtrise des coûts et leur évolution, l’impact que le COVID-19 aura sur Sanofi, ses clients, fournisseurs et partenaires et leur situation financière, ainsi que sur ses employés et sur l’économie mondiale.  Tout impact significatif sur ces derniers pourrait négativement impacter Sanofi. La situation évolue rapidement et d’autres conséquences que nous ignorons pourraient apparaitre et exacerber les risques précédemment identifiés. Ces risques et incertitudes incluent aussi ceux qui sont développés ou identifiés dans les documents publics déposés par Sanofi auprès de l’AMF et de la SEC, y compris ceux énumérés dans les rubriques « Facteurs de risque » et « Déclarations prospectives » du Document d’enregistrement universel 2019 de Sanofi, qui a été déposé auprès de l’AMF ainsi que dans les rubriques « Risk Factors » et « Cautionary Statement Concerning Forward-Looking Statements » du rapport annuel 2019 sur Form 20-F de Sanofi, qui a été déposé auprès de la SEC. Sanofi ne prend aucun engagement de mettre à jour les informations et déclarations prospectives sous réserve de la réglementation applicable notamment les articles 223-1 et suivants du règlement général de l’Autorité des marchés financiers. Pièce jointe PDF

  • Globe Newswire

    Sanofi to evaluate the safety and efficacy of novel investigational candidate THOR-707 and KEYTRUDA® (pembrolizumab) in pursuit of establishing a new treatment option in oncology

    Sanofi to evaluate the safety and efficacy of novel investigational candidate THOR-707 and KEYTRUDA® (pembrolizumab) in pursuit of establishing a new treatment option in oncology *THOR-707 (SAR444245) is a non-alpha IL-2 candidate with a best-in-class profile currently being evaluated in Phase 1 trials for the treatment of solid tumors PARIS – October 29, 2020 – Sanofi has entered into an agreement with Merck & Co., Inc., Kenilworth, NJ, USA (known as MSD outside the U.S. and Canada) to conduct a Phase 2 clinical trial to evaluate the safety, pharmacokinetics, and preliminary efficacy of THOR-707, a highly differentiated non-alpha IL-2 candidate with a best-in-class profile, combined with or in sequenced administration with MSD’s KEYTRUDA® (pembrolizumab) in patients with various cancers. Under the agreement, Sanofi will sponsor the clinical trials while MSD will provide KEYTRUDA. “We believe that THOR-707 has the potential to become a foundation of the next generation of immuno-oncology therapies,” said Peter Adamson, Global Head, Oncology Development and Pediatric Innovation, Sanofi. “This collaboration with MSD will enable us to explore whether THOR-707 can increase and expand the effectiveness of KEYTRUDA and improve the outcomes for patients with cancer.” THOR-707 is currently being evaluated by Sanofi in an ongoing Phase 1 open-label, multi-center, dose escalation and expansion trial.  This study is designed to evaluate the safety and tolerability of THOR-707, and to determine its recommended Phase 2 dose alone and in combination with anti-PD-1 and anti-EGFR antibodies. In addition to testing THOR-707 in combination with KEYTRUDA, Sanofi is separately evaluating the activity of this novel biologic in combination with other anti-PD-1 antibodies, including Libtayo® (cemiplimab-rwlc) and with anti-EGFR and anti-CD38 antibodies for various types of cancer tumors. THOR-707 demonstrated in preclinical studies the ability to induce the expansion of CD8+T-cells resulting in anti-tumor effects both as single agent as well as in combination with an anti-PD1 mAb. It is the first molecule from the Synthorin platform, Sanofi’s unique expanded genetic alphabet platform, which has the potential to create a new generation of precision medicines for oncology and autoimmune disease. About THOR-707 THOR-707 has the potential to be a best-in-class IL-2 therapeutic for the treatment of many types of malignancies and may demonstrate improved pharmacology allowing for less frequent dosing. In pre-clinical experiments, THOR-707 shows striking synergy with anti-PD-1 therapeutics. It is a precisely PEGylated engineered version of interleukin-2 (IL-2), where the PEG chain is attached at a location on IL-2 that prevents it from binding to immune receptors that cause drug toxicities (IL-2R-alpha, CD25) while preserving binding to immune receptors that selectively expand tumor-killing T effector and Natural Killer (NK) cells without the immunosuppressive effects of regulatory T cells or vascular leak syndrome (VLS) inducing eosinophils. Editor’s Note: As discussed at Sanofi’s R&D Day in June, full Phase 1 results for THOR-707 and the recommended Phase 2 dose are expected by 2021.  About Sanofi Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions. With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe. Sanofi, Empowering Life  Sanofi Media Relations Contact Sally Bain Tel.: +1 (781) 264-1091 sally.bain@sanofi.com           Sanofi Investor Relations Contacts Paris Eva Schaefer-Jansen Arnaud DelepineYvonne Naughton Sanofi Investor Relations Contacts North America Felix LauscherFara BerkowitzSuzanne Greco IR main line:Tel.: +33 (0)1 53 77 45 45 ir@sanofi.com Sanofi Forward-Looking StatementsThis press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements are statements that are not historical facts. These statements include projections and estimates and their underlying assumptions, statements regarding plans, objectives, intentions and expectations with respect to future financial results, events, operations, services, product development and potential, and statements regarding future performance. Forward-looking statements are generally identified by the words “expects”, “anticipates”, “believes”, “intends”, “estimates”, “plans” and similar expressions. Although Sanofi’s management believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of which are difficult to predict and generally beyond the control of Sanofi, that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include among other things, the uncertainties inherent in research and development, future clinical data and analysis, including post marketing, decisions by regulatory authorities, such as the FDA or the EMA, regarding whether and when to approve any drug, device or biological application that may be filed for any such product candidates as well as their decisions regarding labelling and other matters that could affect the availability or commercial potential of such product candidates, the fact that product candidates if approved may not be commercially successful, the future approval and commercial success of therapeutic alternatives, Sanofi’s ability to benefit from external growth opportunities, to complete related transactions and/or obtain regulatory clearances, risks associated with intellectual property and any related pending or future litigation and the  ultimate outcome of such litigation,  trends in exchange rates and prevailing interest rates, volatile economic and market conditions,  cost containment initiatives and subsequent changes thereto, and  the impact that COVID-19 will have on us, our customers, suppliers, vendors, and other business partners, and the financial condition of any one of them, as well as on our employees and on the global economy as a whole.  Any material effect of COVID-19 on any of the foregoing could also adversely impact us. This situation is changing rapidly, and additional impacts may arise of which we are not currently aware and may exacerbate other previously identified risks. The risks and uncertainties also include the uncertainties discussed or identified in the public filings with the SEC and the AMF made by Sanofi, including those listed under “Risk Factors” and “Cautionary Statement Regarding Forward-Looking Statements” in Sanofi’s annual report on Form 20-F for the year ended December 31, 2019. Other than as required by applicable law, Sanofi does not undertake any obligation to update or revise any forward-looking information or statements. Attachment PDF

  • Globe Newswire

    Sanofi and GSK to support COVAX with 200 million doses of adjuvanted, recombinant protein-based COVID-19 vaccine

    Sanofi and GSK to support COVAX with 200 million doses of adjuvanted, recombinant protein-based COVID-19 vaccine *COVAX Facility is led by Gavi and aims to secure successful and equitable access to COVID-19 vaccines worldwide PARIS and LONDON – October 28, 2020 – Sanofi and GSK have signed a Statement of Intent with Gavi, the legal administrator of the COVAX Facility, a global risk-sharing mechanism for pooled procurement and equitable distribution of eventual COVID-19 vaccines. Sanofi and GSK intend to make available 200 million doses of their adjuvanted recombinant protein-based COVID-19 vaccine, if approved by regulatory authorities and subject to contract, to the COVAX Facility. Both Companies intend to contribute to COVAX’s ambition to ensure successful COVID-19 vaccines reach those in need, whoever they are and wherever they live, once they obtain appropriate approvals. “To address a global health crisis of this magnitude, it takes unique partnerships. The commitment we are announcing today for the COVAX Facility can help us together stand a better chance of bringing the pandemic under control,” said Thomas Triomphe, Executive Vice President and Global Head of Sanofi Pasteur. “This moment also reflects our long-term commitment to global health and ensures our COVID-19 vaccines are affordable and accessible to those most at risk, everywhere in the world.” Roger Connor, President of GSK Vaccines added, “"Since we started working on the development of COVID-19 vaccines, GSK has pledged to make them available to people around the world. We are proud to be working with Sanofi to make this adjuvanted recombinant protein-based vaccine available to the countries signed up to the COVAX Facility as soon as possible - this has the potential to be a significant contribution to the global fight against COVID-19.” The COVAX Facility is part of COVAX, a global collaboration of governments, global health organizations, businesses and philanthropic organizations working to accelerate development, production, and equitable access to COVID-19 vaccines. COVAX is co-led by Gavi, the Coalition for Epidemic Preparedness Innovations (CEPI) and WHO and forms the vaccines pillar of the Access to COVID-19 Tools (ACT) Accelerator. More than 180 countries and economies recently signed onto the COVAX Facility to get timely and cost-effective access to vaccines to meet the global scale of the COVID-19 pandemic. Through the COVAX Facility’s efforts, vaccines will be distributed in participating countries through the WHO’s recently published Allocation Framework, and the WHO’s Strategic Advisory Group of Experts on Immunization (SAGE) Values Framework which has begun to frame future guidance on vaccine use. These allocation principles aim to ensure that people in all parts of the world will get access to COVID-19 vaccines once they are available. Status of the adjuvanted recombinant protein-based vaccine development Sanofi and GSK initiated a Phase 1/2 study on September 3 with a total of 440 subjects enrolled, and anticipate first results in early December 2020, to support the initiation of a pivotal Phase 3 study before the end of the year. If these data are sufficient for licensure application, it is planned to request regulatory approval from the first half of 2021. In parallel, the Companies are scaling up manufacturing of the antigen and adjuvant respectively. On the front lines in the fight against COVID-19 In addition to the recombinant protein-based vaccine in collaboration with GSK, Sanofi is developing a messenger RNA vaccine in partnership with Translate Bio. With several innovative vaccine platforms currently being investigated across the industry, mRNA is considered among the most promising. Preclinical data showed that two immunizations of the mRNA vaccine induced high neutralizing antibody levels that are comparable to the upper range of those observed in infected humans. Sanofi expects the Phase 1/2 study to start in the fourth quarter of 2020, with earliest potential approval in the second half of 2021. Translate Bio has established mRNA manufacturing capacity and Sanofi expects to be able to supply annual capacity of 90 to 360 million doses. About GSK GSK is a science-led global healthcare company with a special purpose: to help people do more, feel better, live longer. GSK is the leading manufacturer of vaccines globally. For further information, please visit www.gsk.com  About Sanofi Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions. With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe. Sanofi, Empowering Life  Media Relations Contact Nicolas KressmannTel.: +1 732-532-5318Nicolas.Kressmann@sanofi.com                                                                                                                                             Investor Relations Contacts Paris Eva Schaefer-Jansen Arnaud DelepineYvonne Naughton Investor Relations Contacts North America Felix LauscherFara BerkowitzSuzanne Greco IR main line:Tel.: +33 (0)1 53 77 45 45 ir@sanofi.com Sanofi Forward-Looking StatementsThis press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements are statements that are not historical facts. These statements include projections and estimates and their underlying assumptions, statements regarding plans, objectives, intentions and expectations with respect to future financial results, events, operations, services, product development and potential, and statements regarding future performance. Forward-looking statements are generally identified by the words “expects”, “anticipates”, “believes”, “intends”, “estimates”, “plans” and similar expressions. Although Sanofi’s management believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of which are difficult to predict and generally beyond the control of Sanofi, that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include among other things, the uncertainties inherent in research and development, future clinical data and analysis, including post marketing, decisions by regulatory authorities, such as the FDA or the EMA, regarding whether and when to approve any drug, device or biological application that may be filed for any such product candidates as well as their decisions regarding labelling and other matters that could affect the availability or commercial potential of such product candidates, the fact that product candidates if approved may not be commercially successful, the future approval and commercial success of therapeutic alternatives, Sanofi’s ability to benefit from external growth opportunities, to complete related transactions and/or obtain regulatory clearances, risks associated with intellectual property and any related pending or future litigation and the  ultimate outcome of such litigation,  trends in exchange rates and prevailing interest rates, volatile economic and market conditions,  cost containment initiatives and subsequent changes thereto, and  the impact that COVID-19 will have on us, our customers, suppliers, vendors, and other business partners, and the financial condition of any one of them, as well as on our employees and on the global economy as a whole.  Any material effect of COVID-19 on any of the foregoing could also adversely impact us. This situation is changing rapidly and additional impacts may arise of which we are not currently aware and may exacerbate other previously identified risks. The risks and uncertainties also include the uncertainties discussed or identified in the public filings with the SEC and the AMF made by Sanofi, including those listed under “Risk Factors” and “Cautionary Statement Regarding Forward-Looking Statements” in Sanofi’s annual report on Form 20-F for the year ended December 31, 2019. Other than as required by applicable law, Sanofi does not undertake any obligation to update or revise any forward-looking information or statements.  Attachment PDF