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AB Science S.A. (AB.PA)

Paris - Paris Prix différé. Devise en EUR
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15,14-0,28 (-1,82 %)
À la clôture : 5:35PM CET
Plein écran
Clôture précédente15,42
Ouverture15,24
Offre0,00 x 0
Vente0,00 x 0
Var. jour15,06 - 15,30
Sur 52 semaines4,81 - 21,75
Volume127 144
Volume moyen424 007
Cap. boursière671,515M
Bêta (mensuel sur 5 ans)1,05
Rapport P/E (sur 12 mois)S.O.
BPA (sur 12 mois)-0,44
Date de bénéfices30 sept. 2020
Dividende et rendement à termeS.O. (S.O.)
Date ex-dividendeS.O.
Objectif sur 1 an19,05
  • Globe Newswire

    AB Science annonce qu'une nouvelle publication indépendante confirme le rôle du masitinib comme thérapie potentielle dans le cancer du pancréas

    COMMUNIQUE DE PRESSE UNE NOUVELLE PUBLICATION INDÉPENDANTE DANS LA REVUE SCIENTIFIQUE EVALUEE PAR DES PAIRS CELLS CONFIRME LE RÔLE DU MASITINIB COMME THÉRAPIE POTENTIELLE DANS LE CANCER DU PANCRÉAS IDENTIFICATION DE DEUX BIOMARQUEURS TISSULAIRES POUVANT POTENTIELLEMENT SERVIR DE BIOMARQUEURS PRÉDICTIFS DE RÉPONSE AU TRAITEMENT AVEC LE MASITINIB Paris, 23 février 2021, 8h AB Science SA (NYSE Euronext - FR0010557264 - AB) annonce aujourd'hui la publication d'un article évalué par des pairs dans lequel les auteurs concluent que l'inhibition des mastocytes par le masitinib pourrait représenter une nouvelle approche antiangiogénétique dans le cancer du pancréas (les thérapies antiangiogéniques réduisent la croissance des nouveaux vaisseaux sanguins nécessaires aux tumeurs pour se développer et se métastaser). Cet article intitulé ‘Mast Cells Positive for c‐Kit Receptor and Tryptase Correlate with Angiogenesis in Cancerous and Adjacent Normal Pancreatic Tissue’, [1] est librement accessible sur le site de la revue Cells : https://www.mdpi.com/2073-4409/10/2/444 Cette étude a examiné l'activité des mastocytes par immunohistochimie et analyse d'imagerie, dans une série de patients atteints d'un cancer du pancréas non métastatique. Les résultats ont montré que : Divers marqueurs de l'activité des mastocytes ont été augmentés dans le tissu de l'adénocarcinome pancréatique par rapport au tissu normal adjacent.Les mastocytes sont fortement associés à l'angiogenèse dans les tissus cancéreux du pancréas.La densité des mastocytes positifs pour la tryptase (MCDPT) et la surface des mastocytes positifs pour la tryptase (MCAPT) sont des biomarqueurs tissulaires qui pourraient être prédictifs de la réponse au masitinib (traitement anti c‐Kit). Cette étude conforte les résultats de l'étude confirmatoire de phase 3, AB12005, qui a évalué le masitinib à la dose de 6,0 mg/kg/jour en association avec la gemcitabine comme traitement en première ligne des patients atteints d'un cancer du pancréas non résécable localement avancé ou métastatique avec douleur ; la douleur étant supposée être un marqueur de l'activation des mastocytes. Andrew Hendifar, MD, MPH, Chef du service d'oncologie gastro-intestinale de l'hôpital Cedars-Sinai Medical Center à Los Angeles a déclaré : « Ces recherches apportent de nouvelles preuves solides confirmant la pertinence de cibler les mastocytes dans le cancer du pancréas. En outre, les biomarqueurs tissulaires identifiés pourraient potentiellement être utilisés comme marqueur alternatif ou supplémentaire de la douleur lors de l'initiation d'un traitement avec le masitinib chez les patients atteints d'un cancer du pancréas localement avancé ». Pour rappel [2], l’étude AB12005 a atteint son objectif principal de démontrer une augmentation de la survie dans le cancer du pancréas avec douleur. Dans la population de patients avec douleur ayant une tumeur localement avancée non opérable, le masitinib a montré une amélioration significative de la survie globale par rapport au contrôle. La différence de médiane de survie entre les deux groupes est de 1,8 mois (p=0,007) en faveur du masitinib (13,0 mois pour le masitinib versus 11,2 mois pour le contrôle), avec un Hazard Ratio (HR) de décès de 0,46, ce qui représente une réduction du risque de décès de 54% pour les patients traités avec le masitinib par rapport au contrôle. Le résultat sur le critère principal est cohérent avec l'analyse secondaire sur la survie sans progression (SSP), qui mesure le temps jusqu'à la progression de la tumeur ou le décès depuis le début du traitement. La différence entre les groupes sur la médiane de la survie sans progression est de 1,8 mois (p=0,039) en faveur du masitinib (7,4 mois pour le masitinib versus 5,6 mois pour le contrôle), avec un Hazard Ratio de 0,47 représentant une réduction du risque de progression ou de décès de 53%. La tolérance du masitinib à la dose de 6,0 mg/kg/jour en association avec la gemcitabine s'est comparée favorablement à celle de la gemcitabine en monothérapie, avec moins d'événements indésirables et d'événements indésirables graves rapportés dans le bras masitinib par rapport au bras contrôle. [1] Ammendola, M.; Curr, G.; Laface, C.; Zuccal, V.; Memeo, R.; Luposella, F.; Laforgia, M.; Zizzo, N.; Zito, A.; Loisi, D.; et al. Mast Cells Positive for c‐Kit Receptor and Tryptase Correlate with Angiogenesis in Cancerous and Adjacent Normal Pancreatic Tissue. Cells 2021, 10, 444. https://doi.org/10.3390/cells10020444 [2] Communiqué de presse AB Science du 4 décembre 2020. http://www.ab-science.com/years/2020/ A propos de la revue CellsCells est une revue internationale en libre accès, évaluée par des pairs, sur la biologie cellulaire, la biologie moléculaire et la biophysique. Cells est publié mensuellement en ligne par le MDPI. À propos du masitinibLe masitinib est un nouvel inhibiteur de tyrosine kinase, administré par voie orale, qui cible les mastocytes et les macrophages, cellules essentielles de l’immunité, par l’inhibition d’un nombre limité de kinases. En raison de son mode d’action unique, le masitinib peut être développé dans un grand nombre de pathologies, en oncologie, dans les maladies inflammatoires, et certaines maladies du système nerveux central. En oncologie, par son activité d’immunothérapie, le masitinib peut avoir un effet sur la survie, seul ou en association avec la chimiothérapie. Par son activité sur le mastocyte et les cellules microgliales et donc par son effet inhibiteur sur l’activation du processus inflammatoire, le masitinib peut avoir un effet sur les symptômes associés à certaines pathologies inflammatoires et du système nerveux central. À propos d'AB ScienceFondée en 2001, AB Science est une société pharmaceutique spécialisée dans la recherche, le développement, et la commercialisation d'inhibiteurs de protéines kinases (IPK), une classe de protéines ciblées dont l'action est déterminante dans la signalisation cellulaire. Nos programmes ne ciblent que des pathologies à fort besoin médical, souvent mortelles avec un faible taux de survie, rares, ou résistantes à une première ligne de traitement.AB Science a développé en propre un portefeuille de molécule et la molécule phare d'AB Science, le masitinib, a déjà fait l'objet d'un enregistrement en médecine vétérinaire et est développée chez l’homme en oncologie, dans les maladies neurodégénératives et dans les maladies inflammatoires. La Société a son siège à Paris et est cotée sur Euronext Paris (Ticker : AB). Plus d'informations sur la Société sur le site Internet : www.ab-science.com Déclarations prospectives – AB ScienceCe communiqué contient des déclarations prospectives. Ces déclarations ne constituent pas des faits historiques. Ces déclarations comprennent des projections et des estimations ainsi que les hypothèses sur lesquelles celles-ci reposent, des déclarations portant sur des projets, des objectifs, des intentions et des attentes concernant des résultats financiers, des événements, des opérations, des services futurs, le développement de produits et leur potentiel ou les performances futures.Ces déclarations prospectives peuvent souvent être identifiées par les mots « s'attendre à », « anticiper », « croire », « avoir l'intention de », « estimer » ou « planifier », ainsi que par d'autres termes similaires. Bien qu’AB Science estime que ces déclarations prospectives sont raisonnables, les investisseurs sont alertés sur le fait que ces déclarations prospectives sont soumises à de nombreux risques et incertitudes, difficilement prévisibles et généralement en dehors du contrôle d’AB Science qui peuvent impliquer que les résultats et événements effectifs réalisés diffèrent significativement de ceux qui sont exprimés, induits ou prévus dans les informations et déclarations prospectives. Ces risques et incertitudes comprennent notamment les incertitudes inhérentes aux développements des produits de la Société, qui pourraient ne pas aboutir, ou à la délivrance par les autorités compétentes des autorisations de mise sur le marché ou plus généralement tous facteurs qui peuvent affecter la capacité de commercialisation des produits développés par AB Science ainsi que ceux qui sont développés ou identifiés dans les documents publics déposés par AB Science auprès de l'AMF, y compris ceux énumérés dans le chapitre 4 « Facteurs de risques » du document de référence d’AB Science enregistré auprès de l'AMF le 22 novembre 2016, sous le numéro R. 16-078. AB Science ne prend aucun engagement de mettre à jour les informations et déclarations prospectives sous réserve de la réglementation applicable notamment les articles 223-1 et suivants du règlement général de l’AMF. Pour tout renseignement complémentaire, merci de contacter : AB Science Communication financièreinvestors@ab-science.com Relations Médias FranceNewCapArthur Rouilléarouillé@newcap.fr+33 (0)1 44 71 00 15 Relations Médias Etats-UnisRooneyPartnersJeffrey Freedmanjfreedman@rooneyco.com+1 646 532 0191 Pièce jointe Masitinib Pancreas FR VF

  • Globe Newswire

    AB Science announces that a new independent publication confirms the role of masitinib as a potential therapy in pancreatic cancer

    PRESS RELEASE NEW INDEPENDENT PUBLICATION IN THE PEER-REVIEWED SCIENTIFIC REVIEW CELLS CONFIRMS THE ROLE OF MASITINIB AS A POTENTIAL THERAPY IN PANCREATIC CANCER IDENTIFICATION OF TWO TISSUE BIOMARKERS THAT COULD POTENTIALLY SERVE AS PREDICTIVE BIOMARKERS OF RESPONSE FOR MASITINIB TREATMENT Paris, 23 February 2021, 8am CET AB Science SA (NYSE Euronext - FR0010557264 - AB) today announced the publication of a peer-reviewed research article in which the authors conclude that inhibition of mast cells with masitinib could represent a novel antiangiogenetic approach in pancreatic cancer (antiangiogenic therapies reduce the growth of new blood vessels needed by tumors to grow and metastasize). The article, entitled ‘Mast Cells Positive for c‐Kit Receptor and Tryptase Correlate with Angiogenesis in Cancerous and Adjacent Normal Pancreatic Tissue’, [1] is freely accessible online from the Cells journal site https://www.mdpi.com/2073-4409/10/2/444 This study examined mast cell activity through immunohistochemistry and image analysis, in a series of non-metastatic pancreatic cancer patients. Results showed that: Various markers of mast cell activity were increased in pancreatic ductal adenocarcinoma tissue as compared with adjacent normal tissue.Mast cells are strongly associated with angiogenesis in pancreatic cancer tissue. The density of mast cells positive for tryptase (MCDPT) and area of mast cells positive for tryptase (MCAPT) are tissue biomarkers that could be predictive of response to masitinib (anti‐c‐Kit therapy). This research supports results from the confirmatory phase 3 study, AB12005, that evaluated masitinib at 6.0 mg/kg/day in combination with gemcitabine as a first-line treatment of unresectable locally advanced or metastatic pancreatic cancer patients with pain; pain being hypothesized to be a marker of mast cell activation. Andrew Hendifar, MD, MPH, Head of Gastrointestinal Oncology at Cedars-Sinai Medical Center in Los Angeles said: “This research provides new and robust evidence confirming the relevance of targeting mast cells in pancreatic cancer. Furthermore, the identified tissue biomarkers could potentially be used as an alternative or additional marker to pain when initiating masitinib treatment in patients with locally advanced pancreatic cancer.” As a reminder [2], study AB12005 met its primary objective to demonstrate increase in survival in pancreatic cancer patients with pain. In the population with unresectable locally advanced tumors with pain, the masitinib treatment-arm showed a significant improvement in overall survival (OS) relative to the control arm. The between group difference in median OS was 1.8 months (p=0.007) in favor of masitinib (13.0 months in masitinib arm versus 11.2 months in control group), with a 0.46 hazard ratio (HR) of death, which represents a reduction in risk of death of 54% for masitinib-treated patients relative to control. Results on the primary endpoint were consistent with secondary analysis in progression free survival (PFS), which measures the time to tumor progression or death (whichever occurs first) from the start of treatment. The between group difference in median PFS was 1.8 months (p=0.039) in favor of masitinib (7.4 months in masitinib arm versus 5.6 months in control group), with a 0.47 hazard ratio representing a reduction in risk of having a progression or death of 53%. The safety of masitinib 6.0 mg/kg/day in combination with gemcitabine compared favorably to that of gemcitabine as a single agent, with fewer adverse event and severe adverse events reported in the masitinib arm as compared with the control arm. [1] Ammendola, M.; Curr, G.; Laface, C.; Zuccal, V.; Memeo, R.; Luposella, F.; Laforgia, M.; Zizzo, N.; Zito, A.; Loisi, D.; et al. Mast Cells Positive for c‐Kit Receptor and Tryptase Correlate with Angiogenesis in Cancerous and Adjacent Normal Pancreatic Tissue. Cells 2021, 10, 444. https://doi.org/10.3390/cells10020444 [2] AB Science press release. Dec 04,2020. http://www.ab-science.com/years/2020/ About CellsCells is an international, peer-reviewed, open access, journal of cell biology, molecular biology, and biophysics. Cells is published monthly online by MDPI. About masitinibMasitinib is a new orally administered tyrosine kinase inhibitor that targets mast cells and macrophages, important cells for immunity, through inhibiting a limited number of kinases. Based on its unique mechanism of action, masitinib can be developed in a large number of conditions in oncology, in inflammatory diseases, and in certain diseases of the central nervous system. In oncology due to its immunotherapy effect, masitinib can have an effect on survival, alone or in combination with chemotherapy. Through its activity on mast cells and microglia and consequently the inhibition of the activation of the inflammatory process, masitinib can have an effect on the symptoms associated with some inflammatory and central nervous system diseases and the degeneration of these diseases. About AB ScienceFounded in 2001, AB Science is a pharmaceutical company specializing in the research, development and commercialization of protein kinase inhibitors (PKIs), a class of targeted proteins whose action are key in signaling pathways within cells. Our programs target only diseases with high unmet medical needs, often lethal with short term survival or rare or refractory to previous line of treatment. AB Science has developed a proprietary portfolio of molecules and the Company’s lead compound, masitinib, has already been registered for veterinary medicine and is developed in human medicine in oncology, neurological diseases, and inflammatory diseases. The company is headquartered in Paris, France, and listed on Euronext Paris (ticker: AB). Further information is available on AB Science’s website: www.ab-science.com. Forward-looking Statements - AB ScienceThis press release contains forward-looking statements. These statements are not historical facts. These statements include projections and estimates as well as the assumptions on which they are based, statements based on projects, objectives, intentions and expectations regarding financial results, events, operations, future services, product development and their potential or future performance. These forward-looking statements can often be identified by the words "expect", "anticipate", "believe", "intend", "estimate" or "plan" as well as other similar terms. While AB Science believes these forward-looking statements are reasonable, investors are cautioned that these forward-looking statements are subject to numerous risks and uncertainties that are difficult to predict and generally beyond the control of AB Science and which may imply that results and actual events significantly differ from those expressed, induced or anticipated in the forward-looking information and statements. These risks and uncertainties include the uncertainties related to product development of the Company which may not be successful or to the marketing authorizations granted by competent authorities or, more generally, any factors that may affect marketing capacity of the products developed by AB Science, as well as those developed or identified in the public documents filed by AB Science with the Autorité des Marchés Financiers (AMF), including those listed in the Chapter 4 "Risk Factors" of AB Science reference document filed with the AMF on November 22, 2016, under the number R. 16-078. AB Science disclaims any obligation or undertaking to update the forward-looking information and statements, subject to the applicable regulations, in particular articles 223-1 et seq. of the AMF General Regulations. For additional information, please contact: AB ScienceFinancial Communication & Media Relations investors@ab-science.com Media Relations – USA RooneyPartnersJeffrey Freedmanjfreedman@rooneyco.com +1 646 432 0191 Media Relations – France NewCapArthur Rouilléarouille@newcap.fr +33 (0)1 44 71 00 15 Attachment Masitinib Pancreas Eng VF

  • Globe Newswire

    AB Science announces that a new independent publication confirms that masitinib has anti-vital activity against the SARS-CoV-2 virus in vitro and is a promising candidate for treating Covid-19

    NEW INDEPENDENT PUBLICATION CONFIRMS THAT MASITINIB HAS ANTI-VIRAL ACTIVITY AGAINST THE SARS-COV-2 VIRUS IN VITRO AND IS A PROMISING CANDIDATE FOR TREATING COVID-19 Paris, 25 January 2021, 8.30am CET AB Science SA (NYSE Euronext - FR0010557264 - AB) today announced the publication of preclinical study results with masitinib in COVID-19. Research led by scientists from the Institute of Human Virology (Guangzhou, China) has been published in the peer-reviewed journal mBIO (a journal of the American Society for Microbiology). The article, entitled ‘Engineering a reliable and convenient SARS-CoV-2 replicon system for analysis of viral RNA synthesis and screening of antiviral inhibitors’,[1] is freely accessible online from the mBio journal site https://mbio.asm.org/content/mbio/12/1/e02754-20.full.pdf This article reports results of an independent study led by Professor Yuewen Luo and colleagues from the Institute of Human Virology (Guangzhou, China), describing development of a replicon system that has been used for high-throughput screening of antiviral drugs. Replicon systems permit convenient and safe simulation of virus replication to analyze the effects of various SARS-CoV-2 genes, the effects of pandemic SARS-CoV-2 gene variants, and the antiviral activities of small compounds. Starting from a library of 1,680 clinically approved drugs, masitinib was one of just 5 candidate drugs selected for further study due to its potent inhibitory effect upon the replicon system and also its ability to block viral replication of authentic SARS-CoV-2 viruses. In both the replicon system and the authentic SARS-CoV-2 virus, masitinib demonstrated a submicromolar IC50 equal to 0.6 µM (this being a quantitative measure of how much of a particular inhibitory substance is needed to inhibit, in vitro, viral replication by 50%). This value is equivalent to that of masitinib-dependent SARS-CoV-2 replication inhibition in a model of Human Airway Epithelial cells. Importantly, such active concentration (0.6 µM) is reached in human patients at therapeutic dosing (6 mg/kg/day). The authors concluded that their findings supported a hypothesis that the RNA synthesis of SARS-CoV-2 could be directly dependent on a kind of phosphorylation regulation pathway or indirectly dependent on certain receptor tyrosine kinase pathways. These new results show that masitinib, in addition to be a direct antiviral drug blocking the 3CLPro, as was previously shown by research from the University of Chicago [2], could also probably indirectly block virus replication through inhibition of cellular kinases. Thus, masitinib, as an antiviral and an anti-inflammatory drug, might be used at all stages of the COVID-19 disease, alone or in combination with other drugs, including anti-viral drugs and/or dexamethasone. “While vaccines are now available, there is still a need for antiviral and symptomatic treatment for patients infected with the SARS-CoV-2. In addition, the emergence of new, and apparently more transmissible coronavirus variants has prompted concern about whether existing vaccines and monoclonal antibodies will remain effective. This research has shown for a second time that under in vitro conditions masitinib exerts a potent anti-viral effect on the SARS-CoV-2 virus. These results considered in conjunction with data published last year from the University of Chicago [2], further underscore the potential of masitinib as an effective treatment of COVID-19. It provides independent verification of masitinib’s anti-viral action, and importantly reaffirms that the effective inhibitory concentration is at a level that can be achieved in vivo. This latter point strengthens the rationale for the clinical development program of masitinib in COVID-19, and means that extensive clinical testing of masitinib in COVID patients, which is already on-going, is even more essential”, said Professor Olivier Hermine, President of the Scientific Committee of AB Science and member of the Académie des Sciences in France. As a reminder, the University of Chicago article reported results from an independent study led by Professor Savas Tay from the Pritzker School for Molecular Engineering (University of Chicago, USA) [2,3]. Starting from a library of 1,900 clinically used drugs, either approved for human use or in late-stage clinical development, masitinib stood-out in its ability to completely inhibit activity of the SARS-CoV-2 viral replication. Remarkably, the research team elucidated masitinib’s mechanism of action against SARS-CoV-2, showing that masitinib inhibits 3CLpro, the main SARS-CoV-2 protease that is crucial for virus infection and reproduction, by directly binding to the protease catalytic site. AB Science has been granted authorization by French Medicine Agency (ANSM) to initiate a clinical study evaluating masitinib in combination with isoquercetin for the treatment of COVID-19 [4]. This study (AB20001) is a randomized (1:1), open-label Phase 2 clinical trial to evaluate the safety and efficacy of masitinib combined with isoquercetin in hospitalized patients with moderate and severe COVID-19. The study will enroll 200 patients (age ≥18 without an upper age limit) at medical centers in France and other countries. The primary objective is to improve the clinical status of patients after 15 days of treatment. [1] Luo Y, Yu F, Zhou M, et al. 2021. Engineering a reliable and convenient SARS-CoV-2 replicon system for analysis of viral RNA synthesis and screening of antiviral inhibitors. mBio 12:e02754-20. https://doi.org/10.1128/mBio.02754-20. [2] Drayman N, Jones KA, Azizi S-A, et al. Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro. bioRxiv 2020.08.31.274639; doi: https://doi.org/10.1101/2020.08.31.274639 [3] AB Science press release. Sept 02,2020. http://www.ab-science.com/years/2020/ [4] AB Science press release. May 06,2020. http://www.ab-science.com/years/2020/ About mBiomBio is American Society for Microbiology’s first broad-scope, online-only, open access journal. mBio is a bimonthly peer-reviewed open access scientific journal published by the American Society for Microbiology in association with the American Academy of Microbiology. It covers all aspects of the microbiological sciences, including virology, bacteriology, parasitology, mycology, and allied fields. About masitinibMasitinib is a new orally administered tyrosine kinase inhibitor that targets mast cells and macrophages, important cells for immunity, through inhibiting a limited number of kinases. Based on its unique mechanism of action, masitinib can be developed in a large number of conditions in oncology, in inflammatory diseases, and in certain diseases of the central nervous system. In oncology due to its immunotherapy effect, masitinib can have an effect on survival, alone or in combination with chemotherapy. Through its activity on mast cells and microglia and consequently the inhibition of the activation of the inflammatory process, masitinib can have an effect on the symptoms associated with some inflammatory and central nervous system diseases and the degeneration of these diseases. About AB ScienceFounded in 2001, AB Science is a pharmaceutical company specializing in the research, development and commercialization of protein kinase inhibitors (PKIs), a class of targeted proteins whose action are key in signaling pathways within cells. Our programs target only diseases with high unmet medical needs, often lethal with short term survival or rare or refractory to previous line of treatment. AB Science has developed a proprietary portfolio of molecules and the Company’s lead compound, masitinib, has already been registered for veterinary medicine and is developed in human medicine in oncology, neurological diseases, and inflammatory diseases. The company is headquartered in Paris, France, and listed on Euronext Paris (ticker: AB). Further information is available on AB Science’s website: www.ab-science.com. Forward-looking Statements - AB ScienceThis press release contains forward-looking statements. These statements are not historical facts. These statements include projections and estimates as well as the assumptions on which they are based, statements based on projects, objectives, intentions and expectations regarding financial results, events, operations, future services, product development and their potential or future performance. These forward-looking statements can often be identified by the words "expect", "anticipate", "believe", "intend", "estimate" or "plan" as well as other similar terms. While AB Science believes these forward-looking statements are reasonable, investors are cautioned that these forward-looking statements are subject to numerous risks and uncertainties that are difficult to predict and generally beyond the control of AB Science and which may imply that results and actual events significantly differ from those expressed, induced or anticipated in the forward-looking information and statements. These risks and uncertainties include the uncertainties related to product development of the Company which may not be successful or to the marketing authorizations granted by competent authorities or, more generally, any factors that may affect marketing capacity of the products developed by AB Science, as well as those developed or identified in the public documents filed by AB Science with the Autorité des Marchés Financiers (AMF), including those listed in the Chapter 4 "Risk Factors" of AB Science reference document filed with the AMF on November 22, 2016, under the number R. 16-078. AB Science disclaims any obligation or undertaking to update the forward-looking information and statements, subject to the applicable regulations, in particular articles 223-1 et seq. of the AMF General Regulations. For additional information, please contact: AB ScienceFinancial Communication & Media Relations investors@ab-science.com Media Relations – USA RooneyPartnersJeffrey Freedmanjfreedman@rooneyco.com +1 646 432 0191 Media Relations – France NewCapArthur Rouilléarouille@newcap.fr +33 (0)1 44 71 00 15 Attachment Masitinib COVID mBio vEng_VF