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AB Science S.A. (AB.PA)

Paris - Paris Prix différé. Devise en EUR
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16,02-0,18 (-1,11 %)
À partir de 2:25PM CET. Marché ouvert.
Plein écran
Clôture précédente16,20
Ouverture16,32
Offre0,00 x 0
Vente0,00 x 0
Var. jour15,80 - 16,56
Sur 52 semaines4,81 - 21,75
Volume188 350
Volume moyen390 339
Cap. boursière710,546M
Bêta (mensuel sur 5 ans)1,12
Rapport P/E (sur 12 mois)S.O.
BPA (sur 12 mois)-0,44
Date de bénéfices30 sept. 2020
Dividende et rendement à termeS.O. (S.O.)
Date ex-dividendeS.O.
Objectif sur 1 an19,05
  • Globe Newswire

    AB Science announces that a new independent publication confirms that masitinib has anti-vital activity against the SARS-CoV-2 virus in vitro and is a promising candidate for treating Covid-19

    NEW INDEPENDENT PUBLICATION CONFIRMS THAT MASITINIB HAS ANTI-VIRAL ACTIVITY AGAINST THE SARS-COV-2 VIRUS IN VITRO AND IS A PROMISING CANDIDATE FOR TREATING COVID-19 Paris, 25 January 2021, 8.30am CET AB Science SA (NYSE Euronext - FR0010557264 - AB) today announced the publication of preclinical study results with masitinib in COVID-19. Research led by scientists from the Institute of Human Virology (Guangzhou, China) has been published in the peer-reviewed journal mBIO (a journal of the American Society for Microbiology). The article, entitled ‘Engineering a reliable and convenient SARS-CoV-2 replicon system for analysis of viral RNA synthesis and screening of antiviral inhibitors’,[1] is freely accessible online from the mBio journal site https://mbio.asm.org/content/mbio/12/1/e02754-20.full.pdf This article reports results of an independent study led by Professor Yuewen Luo and colleagues from the Institute of Human Virology (Guangzhou, China), describing development of a replicon system that has been used for high-throughput screening of antiviral drugs. Replicon systems permit convenient and safe simulation of virus replication to analyze the effects of various SARS-CoV-2 genes, the effects of pandemic SARS-CoV-2 gene variants, and the antiviral activities of small compounds. Starting from a library of 1,680 clinically approved drugs, masitinib was one of just 5 candidate drugs selected for further study due to its potent inhibitory effect upon the replicon system and also its ability to block viral replication of authentic SARS-CoV-2 viruses. In both the replicon system and the authentic SARS-CoV-2 virus, masitinib demonstrated a submicromolar IC50 equal to 0.6 µM (this being a quantitative measure of how much of a particular inhibitory substance is needed to inhibit, in vitro, viral replication by 50%). This value is equivalent to that of masitinib-dependent SARS-CoV-2 replication inhibition in a model of Human Airway Epithelial cells. Importantly, such active concentration (0.6 µM) is reached in human patients at therapeutic dosing (6 mg/kg/day). The authors concluded that their findings supported a hypothesis that the RNA synthesis of SARS-CoV-2 could be directly dependent on a kind of phosphorylation regulation pathway or indirectly dependent on certain receptor tyrosine kinase pathways. These new results show that masitinib, in addition to be a direct antiviral drug blocking the 3CLPro, as was previously shown by research from the University of Chicago [2], could also probably indirectly block virus replication through inhibition of cellular kinases. Thus, masitinib, as an antiviral and an anti-inflammatory drug, might be used at all stages of the COVID-19 disease, alone or in combination with other drugs, including anti-viral drugs and/or dexamethasone. “While vaccines are now available, there is still a need for antiviral and symptomatic treatment for patients infected with the SARS-CoV-2. In addition, the emergence of new, and apparently more transmissible coronavirus variants has prompted concern about whether existing vaccines and monoclonal antibodies will remain effective. This research has shown for a second time that under in vitro conditions masitinib exerts a potent anti-viral effect on the SARS-CoV-2 virus. These results considered in conjunction with data published last year from the University of Chicago [2], further underscore the potential of masitinib as an effective treatment of COVID-19. It provides independent verification of masitinib’s anti-viral action, and importantly reaffirms that the effective inhibitory concentration is at a level that can be achieved in vivo. This latter point strengthens the rationale for the clinical development program of masitinib in COVID-19, and means that extensive clinical testing of masitinib in COVID patients, which is already on-going, is even more essential”, said Professor Olivier Hermine, President of the Scientific Committee of AB Science and member of the Académie des Sciences in France. As a reminder, the University of Chicago article reported results from an independent study led by Professor Savas Tay from the Pritzker School for Molecular Engineering (University of Chicago, USA) [2,3]. Starting from a library of 1,900 clinically used drugs, either approved for human use or in late-stage clinical development, masitinib stood-out in its ability to completely inhibit activity of the SARS-CoV-2 viral replication. Remarkably, the research team elucidated masitinib’s mechanism of action against SARS-CoV-2, showing that masitinib inhibits 3CLpro, the main SARS-CoV-2 protease that is crucial for virus infection and reproduction, by directly binding to the protease catalytic site. AB Science has been granted authorization by French Medicine Agency (ANSM) to initiate a clinical study evaluating masitinib in combination with isoquercetin for the treatment of COVID-19 [4]. This study (AB20001) is a randomized (1:1), open-label Phase 2 clinical trial to evaluate the safety and efficacy of masitinib combined with isoquercetin in hospitalized patients with moderate and severe COVID-19. The study will enroll 200 patients (age ≥18 without an upper age limit) at medical centers in France and other countries. The primary objective is to improve the clinical status of patients after 15 days of treatment. [1] Luo Y, Yu F, Zhou M, et al. 2021. Engineering a reliable and convenient SARS-CoV-2 replicon system for analysis of viral RNA synthesis and screening of antiviral inhibitors. mBio 12:e02754-20. https://doi.org/10.1128/mBio.02754-20. [2] Drayman N, Jones KA, Azizi S-A, et al. Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro. bioRxiv 2020.08.31.274639; doi: https://doi.org/10.1101/2020.08.31.274639 [3] AB Science press release. Sept 02,2020. http://www.ab-science.com/years/2020/ [4] AB Science press release. May 06,2020. http://www.ab-science.com/years/2020/ About mBiomBio is American Society for Microbiology’s first broad-scope, online-only, open access journal. mBio is a bimonthly peer-reviewed open access scientific journal published by the American Society for Microbiology in association with the American Academy of Microbiology. It covers all aspects of the microbiological sciences, including virology, bacteriology, parasitology, mycology, and allied fields. About masitinibMasitinib is a new orally administered tyrosine kinase inhibitor that targets mast cells and macrophages, important cells for immunity, through inhibiting a limited number of kinases. Based on its unique mechanism of action, masitinib can be developed in a large number of conditions in oncology, in inflammatory diseases, and in certain diseases of the central nervous system. In oncology due to its immunotherapy effect, masitinib can have an effect on survival, alone or in combination with chemotherapy. Through its activity on mast cells and microglia and consequently the inhibition of the activation of the inflammatory process, masitinib can have an effect on the symptoms associated with some inflammatory and central nervous system diseases and the degeneration of these diseases. About AB ScienceFounded in 2001, AB Science is a pharmaceutical company specializing in the research, development and commercialization of protein kinase inhibitors (PKIs), a class of targeted proteins whose action are key in signaling pathways within cells. Our programs target only diseases with high unmet medical needs, often lethal with short term survival or rare or refractory to previous line of treatment. AB Science has developed a proprietary portfolio of molecules and the Company’s lead compound, masitinib, has already been registered for veterinary medicine and is developed in human medicine in oncology, neurological diseases, and inflammatory diseases. The company is headquartered in Paris, France, and listed on Euronext Paris (ticker: AB). Further information is available on AB Science’s website: www.ab-science.com. Forward-looking Statements - AB ScienceThis press release contains forward-looking statements. These statements are not historical facts. These statements include projections and estimates as well as the assumptions on which they are based, statements based on projects, objectives, intentions and expectations regarding financial results, events, operations, future services, product development and their potential or future performance. These forward-looking statements can often be identified by the words "expect", "anticipate", "believe", "intend", "estimate" or "plan" as well as other similar terms. While AB Science believes these forward-looking statements are reasonable, investors are cautioned that these forward-looking statements are subject to numerous risks and uncertainties that are difficult to predict and generally beyond the control of AB Science and which may imply that results and actual events significantly differ from those expressed, induced or anticipated in the forward-looking information and statements. These risks and uncertainties include the uncertainties related to product development of the Company which may not be successful or to the marketing authorizations granted by competent authorities or, more generally, any factors that may affect marketing capacity of the products developed by AB Science, as well as those developed or identified in the public documents filed by AB Science with the Autorité des Marchés Financiers (AMF), including those listed in the Chapter 4 "Risk Factors" of AB Science reference document filed with the AMF on November 22, 2016, under the number R. 16-078. AB Science disclaims any obligation or undertaking to update the forward-looking information and statements, subject to the applicable regulations, in particular articles 223-1 et seq. of the AMF General Regulations. For additional information, please contact: AB ScienceFinancial Communication & Media Relations investors@ab-science.com Media Relations – USA RooneyPartnersJeffrey Freedmanjfreedman@rooneyco.com +1 646 432 0191 Media Relations – France NewCapArthur Rouilléarouille@newcap.fr +33 (0)1 44 71 00 15 Attachment Masitinib COVID mBio vEng_VF

  • Globe Newswire

    AB Science annonce qu'une nouvelle publication indépendante confirme que le masitinib a une activité anti-virale contre le virus SARS-CoV-2 in vitro et est un candidat prometteur pour le traitement du Covid-19

    UNE NOUVELLE PUBLICATION INDÉPENDANTE CONFIRME QUE LE MASITINIB A UNE ACTIVITÉ ANTI-VIRALE CONTRE LE VIRUS SARS-COV-2 IN VITRO ET EST UN CANDIDAT PROMETTEUR POUR LE TRAITEMENT DU COVID-19 Paris, le 25 janvier 2021, 8h30 AB Science SA (NYSE Euronext – FR0010557264 – AB) a annoncé la publication des résultats d'une étude préclinique avec le masitinib dans le COVID-19. Les recherches menées par les scientifiques de l'Institut de Virologie Humaine (Guangzhou, Chine) ont été publiées dans la revue à comité de lecture mBIO (une revue de la Société Américaine de Microbiologie). L'article, intitulé "Engineering a reliable and convenient SARS-CoV-2 replicon system for analysis of viral RNA synthesis and screening of antiviral inhibitors",[1] est librement accessible en ligne sur le site de la revue mBio https://mbio.asm.org/content/mbio/12/1/e02754-20.full.pdf Cet article présente les résultats d'une nouvelle étude indépendante, menée par le professeur Yuewen Luo et ses collègues de l'Institut de virologie humaine (Guangzhou, Chine), décrivant le développement d'un système de réplication virale (réplicon) du SARS-CoV-2 in vitro pour le criblage à haut débit de médicaments antiviraux. De tels systèmes permettent de simuler, de façon pratique et sûre, la réplication du virus SRAS-CoV-2 pour analyser le rôle des différents gènes qu’il code, les effets des mutations desdits gènes ainsi que l’activité antivirale de petites molécules. A partir d'une bibliothèque de 1 680 médicaments cliniquement approuvés, le masitinib a été l'un des cinq médicaments candidats sélectionnés pour une étude plus approfondie en raison de son puissant effet inhibiteur sur le système de réplicon et de sa capacité à bloquer la réplication virale du virus SRAS-CoV-2 sauvage. Dans chacun des modèles, réplicon et SRAS-CoV-2 sauvage, le masitinib a démontré une forte activité avec CI50 submicromolaire égale à 0,6 µM (il s'agit d'une mesure quantitative de la quantité d'une substance inhibitrice particulière nécessaire pour inhiber, in vitro, la réplication virale de 50 %). Cette valeur est équivalente à celle de l'inhibition de la réplication du SARS-CoV-2 par le masitinib dans un modèle de cellules épithéliales des voies respiratoires humaines. Il est important de noter qu'une telle concentration active (0,6 µM) est atteinte chez les patients humains à la dose thérapeutique (6 mg/kg/jour). Les auteurs ont conclu que leurs résultats étayaient l’hypothèse selon laquelle la synthèse de l'ARN du SARS-CoV-2 pourrait être directement dépendante de certaines voies de signalisation régulées par la phosphorylation, le masitinib étant un inhibiteur de tyrosines kinases. Ces nouveaux résultats établissent que le masitinib, en plus d'être un médicament antiviral direct qui bloque la 3CLPro, comme l'ont déjà montré les recherches de l'Université de Chicago [2], pourrait aussi probablement bloquer indirectement la réplication du virus par l'inhibition des kinases cellulaires. Ainsi, le masitinib, en tant qu'antiviral et anti-inflammatoire, pourrait être utilisé à tous les stades de la maladie COVID-19, seul ou en combinaison avec d'autres médicaments, y compris les antiviraux et/ou la dexaméthasone. "Bien que des vaccins soient maintenant disponibles, il existe toujours un besoin de traitement antiviral et symptomatique pour les patients infectés par le SRAS-CoV-2. En outre, l'émergence de nouveaux variants du coronavirus apparemment plus transmissibles a suscité des inquiétudes quant à l'efficacité des vaccins et des anticorps monoclonaux existants. Cette recherche a démontré pour la deuxième fois que, dans des conditions in vitro, le masitinib exerce un puissant effet antiviral sur le virus du SRAS-CoV-2. Ces résultats, considérés conjointement avec les données publiées l'année dernière par l'Université de Chicago [2], soulignent encore davantage le potentiel du masitinib en tant que traitement efficace du COVID-19. Ils fournissent une vérification indépendante de l'action antivirale du masitinib, et réaffirment de manière importante que la concentration inhibitrice efficace est à un niveau qui peut être atteint in vivo. Ce dernier point renforce la justification du programme de développement clinique du masitinib dans COVID-19, et signifie que les essais cliniques approfondis du masitinib chez les patients atteints de COVID, qui sont déjà en cours, sont encore plus essentiels", a déclaré le professeur Olivier Hermine, président du comité scientifique d'AB Science et membre de l'Académie des Sciences. Pour rappel, l'article de l'Université de Chicago rapporte les résultats d'une étude indépendante menée par le professeur Savas Tay de la Pritzker School for Molecular Engineering (Université de Chicago, USA) [2,3]. À partir d'une bibliothèque de 1 900 médicaments utilisés cliniquement, soit approuvés pour un usage humain, soit en phase avancée de développement clinique, le masitinib s'est distingué par sa capacité à inhiber complètement l'activité de la réplication du virus du SRAS-CoV-2. L'équipe de recherche a remarquablement élucidé le mécanisme d'action du masitinib contre le CoV-2 du SRAS, en montrant que le masitinib inhibe la protéase 3CLpro, la principale protéase du CoV-2 du SRAS qui est cruciale pour l'infection et la reproduction du virus, en se liant directement au site catalytique de l‘enzyme. AB Science a reçu l'autorisation de l'Agence nationale du médicament (ANSM) d’initier une étude clinique évaluant le masitinib en association avec l'isoquercétine pour le traitement de COVID-19 [4]. Cette étude (AB20001) est un essai clinique ouvert de phase 2 randomisé (1:1) visant à évaluer la sécurité et l'efficacité du masitinib associé à l'isoquercétine chez des patients hospitalisés atteints de COVID-19 modéré et grave. L'étude recrutera 200 patients (âge ≥18 sans limite d'âge supérieure) dans des centres médicaux en France et dans d'autres pays. L'objectif principal est d'améliorer l'état clinique des patients après 15 jours de traitement. [1] Luo Y, Yu F, Zhou M, et al. 2021. Engineering a reliable and convenient SARS-CoV-2 replicon system for analysis of viral RNA synthesis and screening of antiviral inhibitors. mBio 12:e02754-20. https://doi.org/10.1128/mBio.02754-20. [2] Drayman N, Jones KA, Azizi S-A, et al. Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro. bioRxiv 2020.08.31.274639; doi: https://doi.org/10.1101/2020.08.31.274639 [3] Communiqué de presse AB Science du 3 septembre 2020. http://www.ab-science.com/years/2020/ [4] Communiqué de presse AB Science du 6 mai 2020. http://www.ab-science.com/years/2020/ À propos de mBiomBio est la première revue à large audience et en accès libre, disponible uniquement en ligne, de la société américaine de microbiologie. mBio est une revue scientifique bimestrielle, évaluée par des pairs, publiée par l'American Society for Microbiology en association avec l'American Academy of Microbiology. Elle couvre tous les aspects des sciences microbiologiques, y compris la virologie, la bactériologie, la parasitologie, la mycologie et les domaines connexes. À propos du masitinibLe masitinib est un nouvel inhibiteur de tyrosine kinase, administré par voie orale, qui cible les mastocytes et les macrophages, cellules essentielles de l’immunité, par l’inhibition d’un nombre limité de kinases. En raison de son mode d’action unique, le masitinib peut être développé dans un grand nombre de pathologies, en oncologie, dans les maladies inflammatoires, et certaines maladies du système nerveux central. En oncologie, par son activité d’immunothérapie, le masitinib peut avoir un effet sur la survie, seul ou en association avec la chimiothérapie. Par son activité sur le mastocyte et les cellules microgliales et donc par son effet inhibiteur sur l’activation du processus inflammatoire, le masitinib peut avoir un effet sur les symptômes associés à certaines pathologies inflammatoires et du système nerveux central. À propos d'AB ScienceFondée en 2001, AB Science est une société pharmaceutique spécialisée dans la recherche, le développement, et la commercialisation d'inhibiteurs de protéines kinases (IPK), une classe de protéines ciblées dont l'action est déterminante dans la signalisation cellulaire. Nos programmes ne ciblent que des pathologies à fort besoin médical, souvent mortelles avec un faible taux de survie, rares, ou résistantes à une première ligne de traitement.AB Science a développé en propre un portefeuille de molécule et la molécule phare d'AB Science, le masitinib, a déjà fait l'objet d'un enregistrement en médecine vétérinaire et est développée chez l’homme en oncologie, dans les maladies neurodégénératives et dans les maladies inflammatoires. La Société a son siège à Paris et est cotée sur Euronext Paris (Ticker : AB). Plus d'informations sur la Société sur le site Internet : www.ab-science.com Déclarations prospectives – AB ScienceCe communiqué contient des déclarations prospectives. Ces déclarations ne constituent pas des faits historiques. Ces déclarations comprennent des projections et des estimations ainsi que les hypothèses sur lesquelles celles-ci reposent, des déclarations portant sur des projets, des objectifs, des intentions et des attentes concernant des résultats financiers, des événements, des opérations, des services futurs, le développement de produits et leur potentiel ou les performances futures.Ces déclarations prospectives peuvent souvent être identifiées par les mots « s'attendre à », « anticiper », « croire », « avoir l'intention de », « estimer » ou « planifier », ainsi que par d'autres termes similaires. Bien qu’AB Science estime que ces déclarations prospectives sont raisonnables, les investisseurs sont alertés sur le fait que ces déclarations prospectives sont soumises à de nombreux risques et incertitudes, difficilement prévisibles et généralement en dehors du contrôle d’AB Science qui peuvent impliquer que les résultats et événements effectifs réalisés diffèrent significativement de ceux qui sont exprimés, induits ou prévus dans les informations et déclarations prospectives. Ces risques et incertitudes comprennent notamment les incertitudes inhérentes aux développements des produits de la Société, qui pourraient ne pas aboutir, ou à la délivrance par les autorités compétentes des autorisations de mise sur le marché ou plus généralement tous facteurs qui peuvent affecter la capacité de commercialisation des produits développés par AB Science ainsi que ceux qui sont développés ou identifiés dans les documents publics déposés par AB Science auprès de l'AMF, y compris ceux énumérés dans le chapitre 4 « Facteurs de risques » du document de référence d’AB Science enregistré auprès de l'AMF le 22 novembre 2016, sous le numéro R. 16-078. AB Science ne prend aucun engagement de mettre à jour les informations et déclarations prospectives sous réserve de la réglementation applicable notamment les articles 223-1 et suivants du règlement général de l’AMF. Pour tout renseignement complémentaire, merci de contacter : AB Science Communication financièreinvestors@ab-science.com Relations Médias FranceNewCapArthur Rouilléarouillé@newcap.fr+33 (0)1 44 71 00 15 Relations Médias Etats-UnisRooneyPartnersJeffrey Freedmanjfreedman@rooneyco.com+1 646 532 0191 Pièce jointe Masitinib COVID mBio vFR_VF

  • Globe Newswire

    AB Science announces the success of its capital raise for a total amount of 15 million euros

    NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION, DIRECTLY OR INDIRECTLY, IN OR INTO THE UNITED STATES, CANADA, AUSTRALIA OR JAPAN – THIS PRESS RELEASE IS NOT AN OFFER TO SUBSCRIBE AND IS FOR INFORMATION ONLY PRESS RELEASE AB SCIENCE ANNOUNCES THE SUCCES OF ITS CAPITAL RAISE FOR A TOTAL AMOUNT OF 15.0 MILLION EUROS ·10.5 million euros raised through a private placement and accelerated book-building procedure, without discount, at a price of 14.42 euros per ordinary share.   ·This private placement triggers the conversion of the convertible bonds announced on October 29, 2020 with a nominal value of 4.5 million euros.           Paris, France – December 21, 2020AB Science (the “Company” or “AB Science”, Euronext – FR0010557264 – AB) announces a capital raise of 10.5 million euros by way of issuance of 728,156 new ordinary shares (the “New Shares”). The capital raise was subscribed by European and north American qualified investors (the “Capital Raise”). This Capital Raise did not and will not require the publication of a prospectus subject to the approval of the Autorité des marchés financiers (“AMF”). Use of proceeds The Capital Raise will allow AB Science to strengthen its financial position in order to fund the development of its clinical research program and increase its financing runway beyond the next 12 months.   Terms of the Capital Raise The New Shares have been placed, without shareholders’ preferential subscription rights, by means of a private placement to qualified investors pursuant to the 25th resolution of the combined ordinary and extraordinary general meeting of the shareholders of the Company held on August 31, 2020 (the “General Meeting”) and pursuant to Article L. 225-136 of the French Commercial Code. The issue price of one New Share is 14.42 euros, issue premium included, equal to the volume weighted-average price of the Company’s shares over the last three trading days, consistent with the 25th resolution of the General Meeting. The Company’s shareholding structure after the Capital Raise Following the issuance of the New Shares, the Company’s share capital will be 521,167.99 euros, equal to 52,116,799 shares (including 45,539,935 ordinary shares listed on Euronext Paris) with a par value of 0.01 euro, representing 101.42% of the total current share capital of the Company. It is specified that none of the significant shareholders of AB Science (i.e., holding more than 5% of the share capital) and none of the managers of AB Science are participating in the Capital Raise. Therefore, the capitalization table of the Company will not be materially modified by the Capital Raise. Moreover, AB Science explains that, pending its settlement delivery, the Capital Raise will trigger, given its gross proceeds, the automatic conversion of the convertible bonds announced on October 29, 2020. In line with their subscription agreement, the convertibles bonds will be converted (based on the subscription price of the New Shares) in 312,066 ordinary shares. A penalty of 234,000 euros will be paid to the convertible bonds holders (in cash or in ordinary shares). On an illustrative basis, a shareholder holding 1.00% of the Company’s share capital before the Capital Raise and who did not participate in the Capital Raise will hold 0.99% of the Company’s shares after the Capital Raise (and 0.98% after the conversion of the bonds). Delivery and listing of the New Shares The New Shares will be admitted to trading on Euronext Paris upon their settlement and delivery, which is expected to occur on or about December 31, 2020. They will be listed under the same code as the Company’s existing ordinary shares (ISIN: FR0010557264), carry dividend rights as January 1st, 2020 and be immediately fungible in all respects with the Company’s existing shares. Disclaimer In France, the offer of AB Science securities described above will take place solely as a private placement, in accordance with Article L. 411-2 of the of the French Monetary and Financial Code and applicable regulations. The offering does not constitute a public offering in France, as defined in Article L. 411-1 of the French Monetary and Financial Code. With regard to the Member States of the European Economic Area which have transposed Directive 2003/71/CE of the European Parliament and of the Council of November 4, 2003 (as amended in particular by Directive 2010/73/EU, insofar as this directive has been transposed in each of the Member States of the European Economic Area), no action has been taken and will not be taken to allow a public offer of the securities subject of this press release making necessary to publish a prospectus in either of the Member States. This press release is a promotional communication and is not a prospectus within the meaning of Directive 2003/71/EC of the European Parliament and of the Council, as amended. The distribution, publication or distribution of this press release in certain countries may be subject to restrictions under applicable laws and regulations. Accordingly, persons in such countries in which this press release is issued, published or distributed must inform themselves of and comply with such laws and regulations. This press release and the information it contains does not, and will not, constitute a public offering to subscribe for or sell, nor the solicitation of an offer to subscribe for or buy, securities of AB Science in the United States or any other jurisdiction where restrictions may apply. Securities may not be offered or sold in the United States absent registration or an exemption from registration under the US Securities Act of 1933, as amended and applicable State securities laws. AB Science does not intend to register securities or conduct a public offering in the United States. About AB Science Founded in 2001, AB Science is a pharmaceutical company specializing in the research, development and commercialization of protein kinase inhibitors (PKIs), a class of targeted proteins whose action are key in signaling pathways within cells. Our programs target only diseases with high unmet medical needs, often lethal with short term survival or rare or refractory to previous line of treatment. AB Science has developed a proprietary portfolio of molecules and the Company’s lead compound, masitinib, has already been registered for veterinary medicine and is developed in human medicine in oncology, neurological diseases, and inflammatory diseases. The company is headquartered in Paris, France, and listed on Euronext Paris (ticker: AB). Further information is available on AB Science’s website: www.ab-science.com Forward-looking Statements - AB Science This press release contains forward-looking statements. These statements are not historical facts. These statements include projections and estimates as well as the assumptions on which they are based, statements based on projects, objectives, intentions and expectations regarding financial results, events, operations, future services, product development and their potential or future performance. These forward-looking statements can often be identified by the words "expect", "anticipate", "believe", "intend", "estimate" or "plan" as well as other similar terms. While AB Science believes these forward-looking statements are reasonable, investors are cautioned that these forward-looking statements are subject to numerous risks and uncertainties that are difficult to predict and generally beyond the control of AB Science and which may imply that results and actual events significantly differ from those expressed, induced or anticipated in the forward-looking information and statements. These risks and uncertainties include the uncertainties related to product development of the Company which may not be successful or to the marketing authorizations granted by competent authorities or, more generally, any factors that may affect marketing capacity of the products developed by AB Science, as well as those developed or identified in the public documents filed by AB Science, including those listed in the annual financial report and Chapter 4 "Risk Factors" of AB Science reference document filed with the AMF on November 22, 2016, under the number R. 16-078. AB Science disclaims any obligation or undertaking to update the forward-looking information and statements, subject to the applicable regulations, in particular articles 223-1 et seq. of the AMF General Regulations.   Contacts AB ScienceFinancial Communications & Media Relationsinvestors@ab-science.com   Attachment AB Science CP 21122020 eng VF